Category Archives: Reaction Kinetics Analysis

Reaction Calorimetry For Safe Process Scale-up

httpv://www.youtube.com/watch?v=zsEdnQYuV1c
Reaction calorimetry provides information quickly which can be applied to quantify the risks and criticality associated with a chemical process. Reaction calorimetry helps identify key process parameters, including: Continue reading

Methods For Teaching Chemical Kinetic Experiments

Some of the major challenges faced by researchers (and in particular – organic and analytical chemists) include the need to quickly determine reaction kinetics as well as gain sufficient information to fully understand, characterize and optimize chemical reactions.  This is leading researchers to find innovative ways to obtain the information they require to successfully complete their work.

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How To Monitor Biocatalysis in Real Time

This is the first blog post in a 2 part series in which I will discuss the real-time monitoring of bio-based chemical synthesis.

Biocatalysis continues to evolve, with the application of recombinant organisms or isolated enzymes designed to catalyze specific chemical reactions – often with highly regiospecific and stereospecific conversions. In the optimization of any chemical synthesis reaction – by traditional or biocatalyzed routes – it is not enough to simply report the yield and the enantiameric excess (ee), the kinetics of the reaction must also be considered. Understanding how the kinetics are affected by conditions such as pH and temperature allows optimization of biocatalysis through the identification of operating conditions that can ensure a maximum yield and desired ee in a timely manner. Continue reading

Fundamentals of Process Scale-Up

On November 25 and November 26, Dr. Reinaldo (Ray) Machado of rm2 technologies will conduct a two-day Fundamentals of Scale-up Workshop.  This advanced process scale-up training will be held at the Ramada Powai in Mumbai, India. Continue reading

How Has Organic Chemistry Changed in Academia?

Traditionally, organic chemistry students have been instructed to analyze reactions using standard offline analytical methods, such as High-Performance Liquid Chromatography (HPLC), Nuclear Magnetic Resonance (NMR) Spectroscopy, and Gas Chromatography (GC).

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How To Study Chemistry Under Actual Reaction Conditions

Traditional offline methods to analyze reaction chemistry, such as High-Performance Liquid Chromatography (HPLC), Nuclear Magnetic Resonance (NMR) Spectroscopy, and Gas Chromatography (GC), share a common problem: when a sample is removed for analysis, it may be altered or compromised resulting in significant analytical errors. The solution for this is Continue reading

How To Overcome Process Scale-Up Challenges Using Process Analytical Technology (PAT)

Process Analytical Technology for Scale-up

Process Analytical Technology

During Part I of his two part The Role of Process Analytical Technology (PAT) in Green Chemistry and Green Engineering online seminar series, Dominique Hebrault discussed scale-up challenges faced today by chemists and engineers.  Too often, offline sampling methods – mostly chromatographic methods such as High Performance Liquid Chromatography (HPLC) or Gas Chromatography (GC) – are used to monitor processes which fail to resolve common issues like reaction monitoring, poor mass balance, delayed initiation/reaction stalled, and loss of yield/by-products.  From a reaction engineering standpoint, obtaining heat mass balance information and preliminary kinetic data can be difficult using traditional offline methods during process scale-up.  Forming the final solid can be challenging using traditional offline methods, including filtration/drying a bottleneck, excessive washing, polymorph inconsistency, and batch to batch variability can be difficult.
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How Real-Time In Situ FTIR Advances Organic Chemistry

Advances in Organic Chemistry in Academia

Recent Advances in Organic Chemistry

Paul Scholl will present a free online seminar – Recent Advances in Organic Chemistry in Academia Using Real-Time In Situ FTIR – on July 28.  This on-going series reviews recent advances in organic chemistry by academia where real-time in situ mid-infrared (mid-IR) analytics played a role in the advancement of organic chemistry research.

During the Recent Advances in Organic Chemistry seminar, Paul will discuss several recent publications by academia illustrating how real-time in situ Fourier Transform Infrared spectroscopy (FTIR) was used to help advance the fundamental understanding of organic chemistry. During this series, the following research areas have been discussed:
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How To Streamline Kinetics Studies Using Reaction Progress Kinetic Analysis (RPKA)

Check out this 2-minute video for a quick tour of how Reaction Progress Kinetic Analysis (RPKA) and iC Kinetics can streamline and accelerate kinetics studies.

httpv://www.youtube.com/watch?v=lo2K-hdf8xs

For a more detailed look at RPKA, check out this Free On-Demand Webinar (presented by Prof. Donna Blackmond): Reaction Progress Kinetic Analysis: A Powerful Methodology for Streamlining the Study of Complex Organic Reactions.

The Reaction Progress Kinetic Analysis (RPKA) Methodology, pioneered by Prof. Donna G. Blackmond of The Scripps Research Institute, requires far fewer reaction progress experiments than the classic kinetics approach. It accomplishes this by exploiting the extensive data available from accurate in-situ reaction monitoring under synthetically relevant conditions. The process is further streamlined by iC Kinetics software that automates the math and provides powerful visualizations to guide scientists to an understanding of reaction mechanisms and the selection of optimal reaction conditions.

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