Recently, I met several scientists who did not realize Lasentec® (Lasentech) was acquired by METTLER TOLEDO. It is hard to believe that it has already been 10 years since METTLER TOLEDO acquired Lasentec® and became the world leader for inline particle characterization technology!
Three speakers from the 2010 In-Process Particle Forum will present at IFPAC [International Forum Process Analytical Technology] on January 21, 2011 in Baltimore, MD. Steve Mehrman of Johnson & Johnson and James Butz of Merck & Co. are scheduled to present during the Particle Characterization/Analysis-Ultrasound Spectroscopy Friday AM V session at IFPAC. Kevin Macias of Bristol-Myers Squibb will present during the Control Strategies for Drug Product Development and Manufacturing Friday AM VII session. Continue reading →
Often, I hear questions surrounding what are liquid dosage formulations. I thought I might take the opportunity to provide a short introduction to liquid dosage formulations. Liquid dosage formulations may be in the form of suspensions or syrups, metered dosed inhalers (MDIs), or creams or lotions. All of these systems would typically have particles present or droplets present in their formulations. There could also be parentals, such as injections or intravenous infusions, which may be particle free. Continue reading →
At the 2010 American Institute of Chemical Engineers (AIChE) Annual Meeting in Salt Lake City, there were a number of well-attended sessions dealing with the related topics of Quality by Design (QbD) and Process Analytical Technologies (PAT). Continue reading →
I recently had the pleasure of collaborating with a group of very talented scientists at EMS and International Institute of Pharmaceutical Research (IIPF). EMS and IIPF are two pharmaceutical companies based in Hortolândia, a city roughly 100 miles northwest of Sao Paulo, Brazil. We worked on an interesting project where FBRM was used to track Active Pharmaceutical Ingredient (API) particle size reduction during wet milling. Traditionally, offline laser diffraction had been used to track this process; however this approach proved to be time consuming, prone to inaccuracy and potentially hazardous. Continue reading →
This week, I was in New Orleans attending the 2010 American Association of Pharmaceutical Scientists (AAPS) Annual Meeting. The AAPS Meeting combines a large trade show with technical presentation and poster sessions running in parallel.
At the 2010 AAPS meeting, hot topics included Quality by Design (QbD), Process Analytical Technology (PAT) and the drive towards real-time release for pharmaceutical products. FBRM and PVM technologies were well represented with numerous posters and presentations focusing on their use to understand, optimize and control particle size distribution during drug product formulation. Continue reading →