Category Archives: Fermentation and Bioprocesses

Analysis of Particle Sizes in Process Workshop

The Analysis of Particle Sizes in Process: Measuring Techniques for Emulsions and Suspensions Workshop takes place this week (October 10-12) at the University of Potsdam Institute for Chemistry.  This workshop not only focuses the theory of particle size but also the technology that can be used for real-time, in-process measurements. One of the most interesting sessions will be on the emerging areas where particle size is gaining traction – particle measurement in biotechnology. Continue reading

High Resolution, Fast Understanding, Intuitive Particle Measurement

Inline particle size measurement technology is used to quickly:

  • Understand the particle system’s response when changing process parameters
  • Optimize the particle system to improve process performance and product quality
  • Control the particle system to achieve consistent particle size distribution endpoints, batch repeatability, and process stability Continue reading

How To Optimize Peptide Synthesis

This is the second blog post in a 2 part series where I discuss the real-time monitoring of bio-based chemical synthesis. Continue reading

Advanced Biofuels Leadership Conference: Alternatives for Alternative Fuels


At last week’s Advanced Biofuels Leadership Conference, there was an excellent session highlighting a few of the many different approaches currently being commercialized to develop renewable fuel sources.

What was interesting, is that many seem to be capable of producing fuels or chemicals that are compatible with the existing infrastructure for petroleum refining or directly as petrochemical feedstock. And although the construction of demonstration and full-scale commercial plants might take years to complete, most of the key companies are in the process of planning to scale-up manufacturing within a year.

For my own purposes, I thought it might be useful to list the companies and the route that they are trying to follow towards bulk manufacturing of biofuels and bio-sourced chemicals. If you have additional insight into each of these technologies, or want to voice opinions on their scientific or economic feasibility, please comment below.

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How To Monitor Biocatalysis in Real Time

This is the first blog post in a 2 part series in which I will discuss the real-time monitoring of bio-based chemical synthesis.

Biocatalysis continues to evolve, with the application of recombinant organisms or isolated enzymes designed to catalyze specific chemical reactions – often with highly regiospecific and stereospecific conversions. In the optimization of any chemical synthesis reaction – by traditional or biocatalyzed routes – it is not enough to simply report the yield and the enantiameric excess (ee), the kinetics of the reaction must also be considered. Understanding how the kinetics are affected by conditions such as pH and temperature allows optimization of biocatalysis through the identification of operating conditions that can ensure a maximum yield and desired ee in a timely manner. Continue reading

Process Analytical Technology (PAT) in Fermentation

In Situ Monitoring of Biomass, Cell Growth and Cell Agglomeration

Real-time monitoring of the cell population within a bioreactor provides invaluable information regarding biomass concentration and growth kinetics that can be essential for detailed characterization and control of the fermentation process. Additionally, real-time information related to cell morphology, aggregation, and floc size have also been documented and shown to aid in the understanding and optimization of bioprocesses. Continue reading

Use of Process Analytical Technology (PAT) for Biotech

Process Analytical Technology (PAT) for Biotech: A Review of Recently Reported Applications in Fermentation and BioProcessing

Fermentation and bioprocessing play critical roles in the discovery and manufacture of new pharmaceuticals and specialty chemicals, and in the sustainable production of bulk fuels and commodity chemicals. Yet fermentation processes are often operated with a minimal level of monitoring and control, limiting the ability to optimize yields and production rates. Continue reading

Symposium on Green Processing in the Pharmaceutical & Fine Chemical Industries

Last week, John Tedesco and I had the privilege to attend the 3rd International Symposium on Green Processing in the Pharmaceutical & Fine Chemical Industries in Boston, MA. Continue reading

BIO 2010: Lunch with Bill Clinton and George W. Bush

BIO-2010-Lunch-George-W-Bush-Bill-Clinton At last week’s BIO International Conference in Chicago, I had the chance to sit down to lunch with former Presidents Bill Clinton and George W. Bush. It was a fairly intimate gathering with about 2,000 colleagues (just guessing). Quite honestly, I was in the nose-bleed section, but it was still a memorable opportunity. Click to read the offical news release.

This is not a political blog, so what did two past presidents who had led the USA for most of the past two decades have to do with biotechnology?

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