Category Archives: Crystallization

Amgen Chemical and Process Development Event

With about 80 participants, the Best Practices in Chemical and Process Development Information Sharing Event organized by METTLER TOLEDO and kindly hosted by Amgen in Cambridge, MA on April 10, was clearly a success. It featured best practices presentations around the theme of chemical development in the local pharma industry from Continue reading

19th Larson Workshop – ACT (Association for Crystallization Technology)

I am very much looking forward to attending the 19th Larson Workshop – ACT (Association for Crystallization Technology) conference in Indianapolis  next week (October 6-9).

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AIChE 2013 Spring Meeting and 9th Global Congress on Process Safety

I would like to thank the American Institute of Chemical Engineers (AIChE) and William Hollar (Sabic) for inviting METTLER TOLEDO to present a paper at AIChE Spring 2013 Session in San Antonio last week. The session –  New Approaches in Chemical Manufacturing Operations – Continue reading

Chicago Chemical and Crystallization R&D Event

My colleagues and are hosting a free Chemical and Crystallization R&D Event at the Westin O’Hare Hotel on Thursday, May 23.  The event is aimed towards scientists and researchers working in chemical and crystallization R&D and scale-up. We have six excellent speakers from industry and academia presenting at this event: Continue reading

Process Development Event – Durham, NC

On May 14, my colleagues and I will host an Information Sharing Event at the Marriott Hotel at Research Triangle Park.  This is a free event intended for scientists interested in learning about applications for chemical process development.  We have six speakers from industry and academia for this event: Continue reading

Measuring Fines Precipitation to Improve Solid/Liquid Separations

Poor filtration and bulk density are often related to the number of fine particles present in a system. Inline particle size and count measurements identify the exact moment and conditions when fine particle formation occurs. By pinpointing the source of the inconsistency, the root cause can be identified, and a smarter process may be developed with improved solid/ liquid separations. Continue reading

Best Practice For Inline Particle Size Characterization

 Chemists, engineers, and biologists are often challenged by processes involving particle or droplet systems. Solid or liquid dispersion, homogenization, agglomeration, or precipitation can create variability in product stability and manufacturing throughput. To develop and manufacture world class products at competitive costs, scientists and engineers use inline particle size measurements to optimize process conditions and consistently meet product quality specifications, at the bench or in manufacturing. Continue reading

Advances For Seeding A Crystallization Process

Seeding has become one of the most critical steps in optimizing crystallization behavior, process efficiency, and product quality. Inconsistent filtration rates, drying times, yields, bulk density, flow properties, and particle size distributions can often be traced back to inconsistent seeding and nucleation. Many parameters must be taken into consideration when designing a seeding strategy such as seed size, seed loading (mass) and seed addition temperature. These parameters are generally optimized based on process kinetics and the desired final particle properties and must remain consistent during scale-up and technology transfer. Continue reading

AIChE Annual Meeting 2012

I’m really looking forward to attending the annual American Institute of Chemical Engineers (AIChE) meeting in Pittsburgh, PA this year. It is always a great opportunity to meet excellent scientists working in very diverse areas. As a chemical engineer it is also nice to focus on chemical engineering for a change! – since many of the conferences I attend are chemistry orientated.

It is also great to see so many papers being presented that Continue reading