Category Archives: Continuous Flow Chemistry

Continuous Flow Chemistry Publications

I recently helped some colleagues and customers with literature references on the use of real time in situ mid-IR spectroscopy (ATR-FTIR) applied to flow chemistry. Considering all the reaction condition improvements (yields, purity, simplicity) described in these papers, I thought I would share the list with the chemical community. The papers are from a variety of academic research groups including Klavs Jensen at MIT (USA), Steven Ley and Ian Baxendale at the University of Cambridge (UK), Paul Knochel in Munich (Germany) and Floris Rutjes in the Netherlands. There are also a few papers from Industry, e.g. Merck (USA), and Pfizer (USA). Continue reading

Crystallization Research Information Sharing

I’m really looking forward to the Continuous Flow Chemistry and Crystallization Development Symposium that will take place in New Brunswick, NJ on September 26.  Two colleagues will present new crystallization research that I think will be of interest to the local scientific community.  Continue reading

Continuous Flow Chemistry & Crystallization Development Symposium

In pharmaceutical development, the drive for better drug product quality, process reliability, efficiency and safety have become key factors in driving chemists and engineers to seek alternative methodologies. Continuous flow reactor technologies significantly expand the range and scope of possible chemistries, and allow for rapid testing, optimization, and scaling of chemical sequences. This is reflected in the dramatic increase in the variety and depth of published chemistry over the last few years. Continue reading

Use a Continuous Flow Reactor to Monitor Product Streams & Dispersion Effects

A flow chemistry system in combination with solid-supported reagents and scavengers was used to perform fluorination reactions in a continuous mode.   Using an inline analysis method, the effect of the solid supported reagents and scavengers on the product stream can be investigated.  Continue reading

3rd Symposium on Continuous Flow Reactor Technology for Industry Applications

The 3rd Symposium on Continuous Flow Reactor Technology for Industry Applications will be held October 3 and 4 in Como, Italy.  This Symposium focuses on: Continue reading

American Chemical Society (ACS) Flow Chemistry Resources

As I mentioned prior to the 241st American Chemical Society (ACS) National Meeting and Exposition in Anaheim, there was an Enabling and Optimizing Chemical Reactions in Real Time Flow Chemistry and In Situ Analysis workshop.  Continue reading

Upcoming Continuous Flow Chemistry Events

Regular visitors to this blog will be familiar with recent continuous flow chemistry events in what I consider to be a very exciting, fast-developing area of chemistry. When I was reading the recent blog post regarding the upcoming Pfizer Flow Technology Expo, I thought about other upcoming flow chemistry events, including: Continue reading