Author Archives: Paul Scholl

Understanding Asymmetric Rhodium Catalyzed Carbenoid Reactions

As you may recall, my colleague, Dominique Hebrault, referenced the research of Professor Huw M.L. Davies and his colleagues at Emory University in a presentation that discussed  Continue reading


在2010 年即将过去之际,我将于利用十一月十七日的机会再一次回顾实时原位FTIR在促进学术界化学研究中起的作用。这次网络研讨会是一个系列里的第六部:学术界通过使用实时原位FTIR在有机化学研究上的新进展。在准备此研讨会的过程中,我意识到了原位中红外(in situ mid-IR)的使用是如何地广泛,涉及宽广的化学领域。为了方便起见,我把注意力集中在美国化学学会(ACS)杂志的研究文章上。

从2010年起,美国化学学会(ACS)杂志上发表了28篇列举ReactIR™使用的研究文章 (作为本博客的读者,我设想你们多数都知道ReactIR™ 是一个用中红外光谱专门开发出来进行实时原位分析的专用系统) 。这些文章发表在ACS杂志的Macromolecules, Inorganic Chemistry, JACS, Organometallics, JOC, Organic Letters, 和 Analytical Chemistry。另外, 有两本书的章节里列举了ReactIR™。同时,我注意到三分之一的文章发表在ACS 杂志的Macromolecules 和 Inorganic Chemistry上。

在这即将到来的网络研讨会中,我将通过六篇选出的文章回顾ReactIR™在提供化学洞察力上的作用,从而示范说明原位FTIR 的广泛应用。这些文章出自以下化学研究组:

  • Donald Darensbourg (Texas A&M University)
  • Bernard Rieger (Technical University of Munich, Germany)
  • Ming-Hsi Chiang (Academia Sinica, Tapei, Taiwan)
  • Jason Kingsbury (Boston College)
  • Clark Landis (University of Wisconsin-Madison)
  • David MacMillon (Princeton University)



Recent Chemistry Research from ACS Journals Citing Use of In Situ FTIR

As 2010 comes to a close, I am taking one more opportunity to review the role that real-time in situ FTIR has played in advancing chemical research in academia on November 17. This online seminar is the sixth installment in the series: Recent Advances in Organic Chemistry Research in Academia Through the Use of Real-time In Situ FTIR.  In preparing for this webinar, I have come realize how pervasive the use of in situ mid-IR is across a wide range of chemistry disciplines.  For convenience sake, I focused only on the American Chemical Society (ACS) Journals research articles.

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An Easier Way to Complete Polymer Research Experiments in Academia

University of North Carolina 2010 National Graduate Research Polymer ConferenceThis past week, I attended the National Graduate Research Polymer Conference (NGRPC), which was hosted by the University of North Carolina at Chapel Hill Department of Chemistry.  A well known polymer chemist and professor from another large state university commented without any prompting from me that he really would like to change from using round bottom flasks to using the EasyMax™ for their polymer syntheses.  I saw this as a good opportunity to learn from his perspective what he felt the inherent value was of the EasyMax™, an automated lab reactor system, in academia.

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The Future of Chemical Research and Development: The Demise of the Round Bottomed Flask

ISPE-New-England-Chapter-BioPharma-ConferenceLast Thursday, May 6th, I attended the ISPE (International Society for Pharmaceutical Engineering) New England Chapter Biopharma 2010 Conference held in Warwick, Rhode Island.  A presentation was given by Geraldine Taber, Pfizer’s Global Technology Group Leader titled “Demise of the Round-Bottomed Flask – How new Battle Tools in the Lab of the Future are delivering value for R&D”.

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Recent Advances in Organic Chemistry by Academia Using Real-Time In Situ FTIR (fourier transform infrared spectroscopy) Online Seminar


Recent Advances in Organic Chemistry by Academia

As part of the on-going Recent Advances in Organic Chemistry by Academia Using Real-Time In Situ FTIR online seminar series, Dominique Hebrault will review recent advances in organic chemistry where real-time mid-infrared (mid-IR) analytics played a role in the advancement of organic chemistry research.  This will take place on Wednesday, March 10.

Research topics include:

  • Advances in metal-catalyzed chemical transformations
    • Heterobimetallic for metal carbenoid chemistry as described by Huw M.L. Davies and colleagues at Emory University (United States)
    • Organolithium transformation from Vito Capriati, Saverio Florio, and colleagues from the University of Bari (Italy)
    • Palladium-catalyzed cross-coupling reactions as reported by Aiwen Lei and colleagues at Peking University (China)
    • Ruthenium-catalyzed dynamic kinetic resolution as described by Jan-E. Backvall and colleagues at Stockholm University (Sweden)
  • Highly selective polymerization reactions from Donald J. Darensbourg and colleagues at Texas A&M University (United States)
  • Chemical reactions in supercritical CO2 and system characterization from Paul A. Charpentier and colleagues at University of Western Ontario

Visit the Recent Advances in Organic Chemistry by Academia Using Real-Time In Situ FTIR online seminar page for more information.

Pfizer YouTube video: Process Analytical Technology – Using Mid-IR spectroscopy to monitor a telescoped chemical reaction

Ian Clegg, an Associate Research Fellow at Pfizer Global Research and Development Sandwich Laboratories, United Kingdom recently posted a discussion on LinkedIn’s Process Analytical Technology (PAT) group site titled “PAT data (Mid-IR) posted onto YouTube.”

This YouTube video is entitled “Process Analytical Technology: Using Mid-IR spectroscopy to monitor a telescoped chemical reaction.”


In this video, 3 sequential chemical reactions are run in one vessel without stopping or isolating between reactions, and ReactIR™ (real-time in situ reaction analysis) is used to monitor all 3 reaction phases. All of the key reagents, intermediates and products produce unique peaks which show reaction progression without having to take samples. The video shows the spectra of the reaction as a function of time and how the spectra change. The video shows clearly which peaks were monitored and to which components those peaks correlate.

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