Author Archives: Benjamin Smith

Separations in Mining and Oil Sands Operations

Separation of water from fine tailings in mining and oil sands operations has been a challenge.  To speed water recycle, the density of dispersed particles is increased to form sediments. Continue reading

Measuring Fines Precipitation to Improve Solid/Liquid Separations

Poor filtration and bulk density are often related to the number of fine particles present in a system. Inline particle size and count measurements identify the exact moment and conditions when fine particle formation occurs. By pinpointing the source of the inconsistency, the root cause can be identified, and a smarter process may be developed with improved solid/ liquid separations. Continue reading

Best Practice For Inline Particle Size Characterization

 Chemists, engineers, and biologists are often challenged by processes involving particle or droplet systems. Solid or liquid dispersion, homogenization, agglomeration, or precipitation can create variability in product stability and manufacturing throughput. To develop and manufacture world class products at competitive costs, scientists and engineers use inline particle size measurements to optimize process conditions and consistently meet product quality specifications, at the bench or in manufacturing. Continue reading

HANBAT International Workshop on Industrial and Pharmaceutical Crystallization

Crystallization is a complicated process where the final crystal product is a function of thermodynamics as well as kinetic and physical phenomenon. Continue reading

19th International Workshop on Industrial Crystallization – BIWIC 2012

During BIWIC 2012 (19th International Workshop on Industrial Crystallization) in China, I will present a poster – Amalgamated Sugar Experiences with Inline Particle Size, Shape, and Count Characterization:  Real-Time Crystal Nucleation and Growth Rates in an Industrial Semi-batch Crystallizer. Continue reading

Engineering Fine Particle Size Distributions with Inline Particle Size Measurements

Crystal engineering is applied when the crystal size distribution is too large to meet downstream specifications. By designing the crystallization to produce a fine crystal distribution in situ, downstream milling operations are avoided, thus improving the yield, and reducing energy consumption or safety hazards which may arise due to milling. Continue reading

Improve Oil-Water Droplet Separation to Optimize Oil Recovery

At the 2011 PetroPhase 12 conference in London, we presented a poster showing how inline droplet size measurement is applied to optimize liquid-liquid separations. Continue reading

Petrophase 13 – Optimize Particle-Water-Oil Separations in Dark Crude Oil

The 13th International Conference on Petroleum Phase Behavior and Fouling will be held June 10 – 14, 2012 in St. Petersburg Beach, Florida. Continue reading

Polymorph Form Control: Why Care About Seeding and Cooling Rates?

In Situ Monitoring of Supersaturation and Polymorphic Form of Piracetam during Batch Cooling Crystallization

Mark Barrett and others at the University College Dublin (UCD) recently published a paper Continue reading

Process Analytical Technology (PAT) in CRO/CMO – Why is it important?

On January 25, 2012, I attended an excellent session at the IFPAC Conference where a series of presenters including Lonza, Hovione, Merck, Pfizer, and Bristol-Myers Squibb presented the value of Process Analytical Technology (PAT) and Quality by Design (QbD) within a CRO/CMO (Contract Research Organization/Contract Manufacturing Organization). Continue reading