How to do more with less is a consistent theme in today’s chemical development laboratories. Researchers are challenged with how quickly and cost-effectively they can deliver high quality chemical products and the processes used to make them. This in turn has driven a trend in industry to develop and adopt new methods of working, and new techniques to analyze chemical reactions.
The desire to gain reaction information is not a new one, and offline techniques such as HPLC have been used for many years for this purpose. High Performance Liquid Chromatography (HPLC) provides unrivalled levels of access and sensitivity that enables researchers to gain quantitative information regarding reaction components at any time the reaction is sampled. However, the need to wait for samples to be analyzed results in delays in gaining the required information, which is significant when development speed is of the essence. Also, the inability to see what is happening in between samples, plus a lack of predictive qualities, can sometimes lead to a misunderstanding of reaction progress and mechanism. Because of this, there is a need for instantaneous reaction information to improve the efficiency of the optimization and scale-up of chemistry. In recent years, in situ reaction monitoring has grown in use for chemical reactions.
I will be discussing in situ reaction analysis during a presentation on Friday, November 16 at 4pm during the Southeastern Regional Meeting of the American Chemical Society (SERMACS). SERMACS will be held at the Raleigh Convention Center in North Carolina. If you cannot attend but are interested in this topic, I recommend reading a recently published White Paper: In Situ Monitoring of Chemical Reactions. I hope to see you on Friday!