Crystallization is a complicated process where the final crystal product is a function of thermodynamics as well as kinetic and physical phenomenon. There are two traditional ways of dealing with this complexity of crystallization – either crash the solids out of solution and deal with the results downstream, or tune down the crystallizer to avoid common problems. Neither of these situations is optimized for assuring product quality or maximizing production yield and throughput. This has fuelled a push towards real-time monitoring of crystallization with in-process particle measurement technology that can directly measure critical parameters such as the crystal size and count distribution without sampling or sample preparation. During HANBAT International Workshop on Industrial and Pharmaceutial Crystallization in Korea, I will present the poster – Changing the Paradigm for Inline Nucleation and Crystal Growth Measurements to Optimize Crystallization Performance.
By measuring dynamic changes to crystals through growth, breakage, dissolution, or agglomeration mechanisms, inline tools provide detailed information that enables improvements in yield, purity, product consistency, and downstream throughput. Yet up to now interpreting measurement artifacts has been a challenge.
The New Generation of FBRM® technology makes interpreting crystallization mechanisms even easier. By improving Chord Length accuracy, eliminating convoluting surface feature measurements, correcting for crystal fouling, and increasing the dynamic range, the next generation FBRM® provides more intuitive information while tracking critical product parameters with both higher precision and improved accuracy. This poster aims to discuss how new improvements in design, coupled with the use of the latest electronic and software technology, have enabled the next generation FBRM® to surpass its capable predecessors. Specific case studies will demonstrate how new innovations in FBRM® technology offer specific enhancements enabling scientists to understand and optimize crystallization more effectively. Examples include:
- Improved correlation with downstream product quality and process efficiency (filtration)
- Better resolution to crystallization and nucleation and growth kinetics
- Enhanced sensitivity to secondary nucleation and polymorph detection
- Improved accuracy by detecting and correcting for particles which stick to the probe window
You can learn more in the White Paper: Inline Particle Size Measurement – Changing the Paradigm.