A flow chemistry system in combination with solid-supported reagents and scavengers was used to perform fluorination reactions in a continuous mode. Using an inline analysis method, the effect of the solid supported reagents and scavengers on the product stream can be investigated. Continue reading
The desire to gain major improvements in product quality, yield, synthetic route, cycle time and safety in chemical processes have become key driving factors for chemists and engineers working in the chemical development and manufacturing environment in the pharmaceutical and fine chemical industries. In order to achieve these goals, scientists are actively seeking alternative chemical development methods such as modern continuous flow reactor technologies. These technologies provide the opportunity to address many of these issues as they allow for rapid testing, optimization, and scaling of chemical sequences, many of which are unsafe for batch operations.