How To Transfer Crystallization To Manufacturing Or Contract Partner

Transferring a crystallization to manufacturing or a contract partner is a critical step.


Chemists and Engineers use inline particle size measurements to troubleshoot batch inconsistencies, improve filtration, and eliminate batch failure.

This 1 minute video shows how:

  • GlaxoSmithKline applied inline FBRM technology to determine the root cause of significant batch inconsistencies during crystallization scale up.  The inline crystal size distribution was used to detect an inconsistency in the seed size and surface area – only 8 minutes after seed addition.
  • Scientists corrected the source of variability, saving over 14 hours of processing time, improving throughput, and ensuring product consistency upon scale-up to manufacturing.

Airiau, C. et al GSK, EPIC09

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