Highly reactive chemistry is the generic term referring to chemical reactions that pose a challenge due to the potentially hazardous and/or energetic nature of the reactants, intermediates and products that are present during synthesis. Highly reactive chemistries include Grignard, acid chloride, azide, halogenation, and hydrogenation.
The guide – Optimization of Highly Reactive Chemistry – provides examples of the safe process scale-up and optimization of highly reactive chemistries and outlines how to:
- Determine optimal process conditions to deliver high yields of desired product
- Follow reaction progression while eliminating direct exposure to dangerous reaction materials
- Prevent runaway reactions or explosions