How To Study Chemistry Under Actual Reaction Conditions

Traditional offline methods to analyze reaction chemistry, such as High-Performance Liquid Chromatography (HPLC), Nuclear Magnetic Resonance (NMR) Spectroscopy, and Gas Chromatography (GC), share a common problem: when a sample is removed for analysis, it may be altered or compromised resulting in significant analytical errors. The solution for this is In Situ Fourier Transform Infrared (FTIR) Reaction Analysisin situ Fourier Transform Infrared (FTIR) analysis.  In situ FTIR analysis is ideal for studying chemistry as it actually exists in the reactor, eliminating time delays and errors resulting from “grab sampling” analysis.

Today, I would like to address one question that is often asked:

Why Use In Situ FTIR Analysis Over Offline Methods To Analyze Reaction Chemistry?

  • A critical intermediate may be present that is lost in offline sampling
  • Air, accidentally introduced when a sample was removed for analysis, can change the chemistry
  • Reaction toxicity is significant enough to prohibit exposure
  • The reaction is run under pressure and/or extreme temperatures – removing a sample may alter the chemistry, invalidating the analysis

In situ FTIR analysis can be used for any kind of chemistry, including:

  • Corrosive chemistry
  • High temperatures and pressure
  • Slurries, catalysts and particles
  • H2O or any organic solvent-based system
  • Acidic or Basic

On November 17, Paul Scholl will go into further detail on this topic during the Recent Advances in Organic Chemistry Using In Situ FTIR Analysis webinar.  Paul will discuss several recent publications from the areas of Organic Synthesis, Catalysis, Organometallics, Polymer Synthesis, and Reaction Kinetics where in situ FTIR analysis has been used to better understand a reaction.