BIWIC 2010: Optimization & Scale-up of Anti-Solvent Crystallization

Later this week, scientists and engineers will join together at Martin Luther University Halle-Wittenberg in Germany for the BIWIC 2010 – International Workshop on Industrial Crystallization.  Topics at this year’s International Workshop on Industrial Crystallization will include fundamentals of crystallization (thermodynamics and kinetics), process design (monitoring and modeling), product design (polymorphism, salvation, stability, chiral separation, fine chemicals, pharmaceuticals), industrial applications, and intensified processes and equipment (external fields, micro technology, hybrid processes).

BIWIC 2010 International Workshop on Industrial CrystallizationOne highlight of BIWIC 2010 will be Jöchen Schoell’s presentation – The Optimization and Scale-up of an Anti-Solvent Crystallization: From Lab to Pilot Plant. While introducing his presentation, Jöchen will discuss why Process Analytical Technology (PAT) is used for crystallization processes.  Jöchen will then review a case study from academic research based on the Ph.D. work of Dr. Mark Barrett of Solid State Pharmaceutical Cluster (SSPC).  During this research, the application of Process Analytical Technology (PAT) in a “Scale-up Toolbox” was used to understand, characterize and optimize an anti-solvent crystallization at laboratory scale.  Optimization of a seeding protocol and anti-solvent methodology enabled the design of a robust crystallization process that was used to effectively scale-up from an initial crystallizer volume of 500mL to 2L to 100L.  Recommendations for crystallization scale-up as well as the conclusions drawn from this research will conclude the presentation.

For those of you not able to attend Jöchen’s session at BIWIC 2010, Dr. Mark Barrett recorded a presentation discussing his academic research – Optimization and Scale-up of Anti-Solvent Addition Crystallizations From Lab to Pilot Plant – which is now available on-demand.

If you are interested in discussions with others working and interested in crystallization, consider joining the 500+ member LinkedIn Crystallization Community.