Safe Scale-up of a Grignard Reaction – LinkedIn OPRD Group

Recently, I saw a conversation on the LinkedIn Organic Process Research & Development (OPRD) Group that began with the subject:  “Precaution during scale-up of a Grignard reaction?”.  This discussion regarding the safety of Grignard reactions on scale made me realize how useful old chemical reactions can be, although not necessarily well-understood or controlled.

Grignard Reaction LinkedIn OPRD GroupAs of August 12, 2010, the number of comments in this LinkedIn OPRD discussion was 23 – and in only one month.  For me, this illustrates the concern many chemists and engineers have regarding the use of a Grignard reaction on a large scale.  RC1e reaction calorimetry and ReactIR in situ FTIR spectroscopy – either independently or in combination – are excellent methods to make sure the Grignard reaction will be safe on scale.

Some great papers on the topics from Organic Process Research & Development (OPRD) include:

  • Safety Improvements of a Grignard Reaction by Controlling the Reactant Feed, 2006, 10, 1282-1286 and 2005, 9 (3), 365 -371
  • Preparation of Grignard Reagents: FTIR and Calorimetric Investigation for Safe Scale-up, 1999, 3(5), 319-329
  • Activation of Mg Metal for Safe Formation of Grignard Reagents on Plant Scale, 2002, 6, 906-910

Simon Rea gave an interesting  presentation on this topic as well – Identifying  Non-Scalable Reaction Conditions at Small Scale – which is now available on-demand.

Digg This
Reddit This
Stumble Now!
Buzz This
Vote on DZone
Share on Facebook
Bookmark this on Delicious
Kick It on
Shout it
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)