Arguably, kinetics is one of the least popular subjects in academic or industrial research. During her recent webinar – Reaction Progress Kinetic Analysis: A Powerful Methodology for Streamlining the Study of Complex Organic Reactions, Donna Blackmond reiterated why having kinetic data can be valuable:
- Improved Process Safety – Kinetic data can provide understanding of the driving force behind reactions and how substrate concentrations affect processes, which leads to safer processes
- Better Process Understanding – A better understanding of the reaction mechanism leads to a faster optimal synthetic route
- More Robust Process – Better process knowledge leads to more consistent processes
Historically, kinetic analysis has not played a more central role due to the way kinetic data is collected. Pioneered by Donna Blackmond of the Scripps Research Institute, the Reaction Progress Kinetic Analysis (RPKA) methodology simplifies kinetic studies of organic reactions in fewer experiments.