The particle size distribution is a critical parameter in process efficiency and product quality in many pharmaceutical, chemical and industrial processes. The real-time measurement of particle count, dimension and shape of particles as they actually exist in process provides critical process information that speeds up process understanding and enables a better means of real-time measurement and control.
At next week’s World Congress on Particle Technology in Nuremburg, two of my colleagues will be presenting papers covering research and case studies covering a variety of applications of real-time measurement of particle systems using on-line particle characterization tools.
The titles of the four papers that will be presented are listed below :
- Advanced In Situ Tools for the Optimization and Scale-up of Crystallization Processes, Jochen Schoell, Ian Haley, Des O’Grady, Brian O’Sullivan, Benjamin Smith (METTLER TOLEDO, Columbia, MD, USA)
- Monday, April 26, 14:30, T0211: Crystallisation – Design, Scale-up and Control, OSLO (2)
- Optimization and Scale-up of High Shear Wet Granulation Processes Using FBRM® and PVM® In Situ Particle Characterization, Benjamin Smith1, Zane Arp2, Thomas Vermieire3, Eric Dycus1, Ian Haley1, (1METTLER TOLEDO, Columbia, MD, USA; 2GlaxoSmithKline, King Of Prussia, PA, USA; 3GEA Pharma Systems, S-Hertogenbosch, The Netherlands)
- Tuesday, April 27, 16:40, T0512: Granulation – Wet Granulation, KOPENHAGEN (2)
- Real time, in situ particle monitoring during roller compaction, Benjamin Smith2, Ronak Vakil1, Des O’Grady2, Harbhagwan Kalia1, Jane Riley2, Colleen Ruegger1, (1Novartis Pharmaceuticals, East Hanover, NJ, USA; 2Mettler-Toledo AutoChem, Columbia, MD, USA)
- Wednesday, April 28, 16:20, T0521: Granulation – Dry Granulation, ISTANBUL (2)
- Advanced In Situ Tools for the Optimization and Scale-up of Fluid Bed Processes, Jochen Schoell1, Andrew Birkmire2, Michael Melichar2, Brian O’Sullivan1, Eric Dycus1, Benjamin Smith1, (1METTLER TOLEDO, Columbia, MD, USA; 2GEA Pharma Systems, Columbia, MD, USA)
- Thursday, April 29, 14:30, T0502: Granulation, RIGA (2)
If you are interested in receiving a copy of any of these presentations, leave a comment below or request additional info. (Mention the POWTECH Blog Post and we’ll know what you’re looking for).
FBRM (Focused Beam Reflectance Measurement) and PVM (Particle Video Microscopy) are probe-based techniques that measure and image particles and droplets as they actually exist in process – without the problems and particle system changes caused by withdrawing and preparing samples for at-line or off-line analysis. Measuring particles in-process using process analytical tools enables dynamic modeling of particle growth, aggregation, flocculation and breakage – for a more detailed process understanding and more effective optimization and process monitoring and control.
For more information, you can also check out our website describing these on-line particle characterization tools and their powerful applications in pharmaceuticals, fine chemicals, and other particulate processes.