A successful process based on roller compaction followed by milling should produce a granule with consistent particle size distribution, density, and porosity control. Inconsistencies often occur during granulation scale-up due to changing raw materials or changing process dynamics.
The application of FBRM®, real time particle characterization, is demonstrated at-line to map the design space and optimize a series of roller compaction runs while varying vertical feed speed, horizontal feed speed, roller compaction force, and mill speed.
This extended abstract summarizes collaborative research between Patheon Pharmaceuticals and METTLER TOLEDO in the application of process analytical technologies (PAT) to optimization of Dry Granulation using Roller Compaction.
Download the extended abstract from this conference presentation at the 7th World Meeting on Pharmaceutics, Biopharmaceutics, and Pharmaceutical Technology.
G. Burke, Patheon
A. Pandey, D. O’Grady, B. Smith, METTLER TOLEDO
This is the last of four posters was presented by my colleagues, Ian Haley and Ben Smith, at the 7th World Meeting on Pharmaceutics, Biopharmaceutics, and Pharmaceutical Technology in Malta from March 8-11, 2010.
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