One goal of high shear granulation is to yield repeatable endpoint granule size, shape, and density distributions. This is necessary for consistent downstream flow properties, tablet consistency, and content uniformity. Quality by Design (QbD) is a concept applied to gain true process understanding through tools such as Design of Experiment (DoE), risk management, and Process Analytical Technology (PAT).
This extended abstract summarizes collaborative research between GlaxoSmithKline (GSK) and METTLER TOLEDO in the application of process analytical technologies (PAT) to the monitoring, optimization and control of High Shear Wet Granulation.
Zane Arp, GSK
Eric Dycus, Ben Smith, METTLER TOLEDO
This is the second of four posters to be presented by my colleagues, Ian Haley and Ben Smith, at the 7th World Meeting on Pharmaceutics, Biopharmaceutics, and Pharmaceutical Technology in Malta from March 8-11, 2010.
Visit our 7th World Meeting on Pharmaceutics, Biopharmaceutics, and Pharmaceutical Technology information page for this event for more information and additional abstracts.
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