A flow chemistry system in combination with solid-supported reagents and scavengers was used to perform fluorination reactions in a continuous mode. Using an inline analysis method, the effect of the solid supported reagents and scavengers on the product stream can be investigated. Read more »
Tags: chemistry, continous, dispersion, effects, flow, flow chemistry, fluorination, infrared, ir, monitor, product, reactions, reagents, scavengers, Spectroscopy, streams, system
April 10, 2012 1:16 pm | Adrian Burke | 
Continuous Flow Chemistry | 
Comments (0)
Cyclopentadecanone monooxygenase (CPDMO), a Baeyer-Villiger monooxygenase (BVMO), is an enzyme proven to be effective in the biotransformation of large and small cyclic ketones to lactones and offers high chemo-, regio-, and enantioselectivity. Read more »
Tags: Baeyer-Villiger, biocatalysis, biotransformation, biotransformations, BVMO, catalysis, CPDMO, Cyclopentadecanone monooxygenase, enzymatic, enzyme, ketones, lactones, ReactIR (ATR FTIR), Vaso Vlachos, white paper
April 5, 2012 11:35 am | Vaso Vlachos | ReactIR (ATR FTIR) | Comments (0)
The desire to gain major improvements in product quality, yield, synthetic route, cycle time and safety in chemical processes have become key driving factors for chemists and engineers working in the chemical development and manufacturing environment in the pharmaceutical and fine chemical industries. In order to achieve these goals, scientists are actively seeking alternative chemical development methods such as modern continuous flow reactor technologies. These technologies provide the opportunity to address many of these issues as they allow for rapid testing, optimization, and scaling of chemical sequences, many of which are unsafe for batch operations.
Tags: chemical development, chemistry, Continuous Flow Chemistry, continuous processes, flow, flow chemistry, flow chemistry white paper, white paper
April 3, 2012 9:02 am | Adrian Burke | Reaction Analysis, ReactIR (ATR FTIR) | Comments (0)
Tags: 10th International Workshop on Crystal Growth of Organic Materials, ACTS-2012, AIChE Annual Meeting, AIChE Process Development Symposium, American Institute of Chemical Engineers, BIWIC, CGOM10, Chemical Engineering & Technology, Chemical Engineers, Chinese Journal of Chemical Engineering, Conferences, crystal, crystal growth, Crystallization, crystallization community, ECCG4, European Conference on Crystal Growth, events, First Asian Crystallization Technology Symposium, International School of Crystallization, International Workshop on Industrial Crystallization, journal, Journal of Chemical Engineering & Technology, journal of crystal growth, LinkedIn, LinkedIn Crystallization Community, meetings, Process Development and Scale-up, SCI, SCI&EI, Tianjin University, Workshop on Crystal Growth of Organic Materials
March 8, 2012 9:23 am | Des O'Grady | Crystallization, Process Development and Scale-up | Comments (0)
In Situ Monitoring of Supersaturation and Polymorphic Form of Piracetam during Batch Cooling Crystallization
Mark Barrett and others at the University College Dublin (UCD) recently published a paper Read more »
Tags: batch, cooling, Crystallization, design of experiments, DoE, FBRM, form, in situ, Mark Barrett, metastable, metastable zone with, particle, particle size, particle size distribution, polymorph, polymorphic, Raman, ReactIR (ATR FTIR), seeding, Spectroscopy, UCD, University College Dublin, width, zone
March 5, 2012 12:24 pm | Benjamin Smith | Crystallization, FBRM, Particle System Characterization, Reaction Analysis, ReactIR (ATR FTIR) | Comments (0)
On January 25, 2012, I attended an excellent session at the IFPAC Conference where a series of presenters including Lonza, Hovione, Merck, Pfizer, and Bristol-Myers Squibb presented the value of Process Analytical Technology (PAT) and Quality by Design (QbD) within a CRO/CMO (Contract Research Organization/Contract Manufacturing Organization). Read more »
Tags: 2012, CMO, conference, Contract Manufacturing Organization, Contract Research Organization, CRO, Crystallization, IFPAC, PAT, process analytical technology, QbD, quality by design
February 27, 2012 8:10 am | Benjamin Smith | PAT and QbD | Comments (0)
Tags: CMO, Contract Manufacturing, Contract Manufacturing Organization, Crystallization, crystallization process, crystallization workstation, facility, manufacturing, manufacturing facility, measurement, monitoring, particle, particle size, pipeline, process, Process Development and Scale-up, process monitoring, size, tools, vessel, workstation
February 14, 2012 1:37 pm | Benjamin Smith | Crystallization, Process Development and Scale-up | Comments (0)
Transferring a crystallization to manufacturing or a contract partner is a critical step.
Tags: batch, batch inconsistencies, contract, contract partner, crystal, Crystallization, distribution, GlaxoSmithKline, manufacturing, particle, scale-up, size, transfer
February 5, 2012 5:21 pm | Benjamin Smith | Crystallization, FBRM | Comments (0)
Chemists and Engineers need to quickly develop repeatable crystallization processes with fast cycle times. Read more »
Tags: batch consistency, chemists, crystal, crystal size, crystal size distribution, Crystallization, crystallization workstation, distribution, engineers, Excella, FBRM, filtration, Germany, measurement, nucleation, optimax, particle, particle size, particle size distribution, particle size measurement, PVM, rates, researchers, size, University College Dublin, workstation
January 27, 2012 12:40 pm | Benjamin Smith | Crystallization, FBRM, PVM | Comments (0)
USP dissolution testing is a standard method in pharmaceutical industry to characterize dissolution performance of solid dosage forms. Read more »
Tags: analysis, Carrie Coutant, disintegration, dissolution, Eli Lilly, FBRM, Focused Beam Reflectance Measurement, forms, particle, particle size, root cause, size, solid dosage, studies, study, tablet, USP
January 20, 2012 8:00 am | Anjan Pandey | FBRM, Particle System Characterization, Pharma Formulations - Solids | Comments (0)
